A paper from Professor Gang's group is featured on the February 2022 issue of JACS. In the paper, an open, three-dimensional (3D) DNA wireframe octahedron is used to create a library of spatially arranged organizations of enzymes. The contribution of enzyme spacing, arrangement, and location on the 3D scaffold to cascade activity is explored. The experiments provide insight into enzyme scaffold design and allow us to determine that enzyme colocalization itself dominates improvements to enzyme activity.
Read more here: https://doi.org/10.1021/jacsau.1c00387